Bivalirudin (ATC

code B01A) - an organic compound, an an ti-drug group specific direct thrombin inhibitor (DTI). Bivalirud in inhibits thrombin in both the liquid fraction and the fraction associated with the clot, which prevents cleavage by thrombin of fibrinogen into fibrin monomers, activation of factors XIII, V, VIII and stimulate platelets to aggregate. The medicine is characterized by the linear pharmacokinetics. In 1998, the FDA refused to register bivalirudin for treatment of patients with unstable coronary artery disease eligible for angioplasty.